Late-Onset Epilepsy Linked to Greater Hazard for Loss of life in More mature Grown ups

As opposed with people with no epilepsy, these with late-onset epilepsy may possibly be at…

As opposed with people with no epilepsy, these with late-onset epilepsy may possibly be at enhanced chance for dying, even right after modifying for comorbidities, according to research conclusions published in Neurology. In addition, the scientists discovered that grown ups with late-onset epilepsy (starting off at ≥65 yrs) experienced a larger mortality danger owing to stroke and dementia.

While epilepsy has been demonstrated to raise the mortality possibility relative to the common population, considerably less is recognised with regards to the association between late-onset epilepsy and the possibility for demise.

To examine this affiliation, the researchers of the current analyze analyzed facts from the possible Atherosclerosis Risk in Communities (ARIC) review, the Cohort Component of which commenced in 1987.

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The ARIC research integrated a complete of 15,792 folks, a majority of whom were Black and White males and women of all ages aged concerning 45 and 65 many years in 4 communities in the US. Members had been adopted up with 7 in-particular person visits by way of 2018 and have been contacted annually by phone.

Scientists of the ARIC review collected healthcare facility discharge records and data on demise certificates of all contributors. Participant information were being connected to Centers for Medicare and Medicaid Expert services (CMS) Medicare promises facts.

A overall of 678 clients of the 9090 contributors with sufficient CMS info created late-onset epilepsy in the course of adhere to-up (29 for each 1000 man or woman-several years). Individuals with late-onset epilepsy had been identified at 67 years.

At the conclusion of 2018, a appreciably better proportion of clients with late-onset epilepsy experienced died as opposed with the ARIC participants with out epilepsy (54% vs 34.9%, respectively P <.005). In patients with late-onset epilepsy, the median duration of survival following the first seizure code was 4.79 years.

After the age of 67 years, the mortality rates in those with vs without late-onset epilepsy were 49.76 per 1000 person-years vs 33.68 per 1000 person-years, respectively (incident rate ratio [IRR], 1.48 95% CI, 1.35-1.62).

An analysis of ARIC participants with late-onset epilepsy who did not have stroke or dementia showed an increased IRR for mortality of 1.57 (95% CI, 1.36-1.81), as well as an adjusted hazard ratio of mortality of 3.11 (95% CI, 2.69-3.62). Among individuals with stroke and dementia, there was no significant difference between participants with vs without late-onset epilepsy with regard to mortality (IRR, 1.09 95% CI, 0.81-1.45).

Compared with ARIC participants without late-onset epilepsy, those with late-onset epilepsy had higher rates of deaths caused by stroke (4.3% vs 9.3%, respectively P <.005) and dementia (8.9% vs 15.8%, respectively P <.005).

A limitation of this study was the reliance on CMS Medicare claims data for identifying cases of late-onset epilepsy and the lack of information about the severity of epilepsy, a potentially crucial metric in determining risk for mortality and stroke.

The researchers concluded that the observed “mortality risks suggest that clinicians should address modifiable vascular risk factors with lifestyle and medication changes as appropriate” in patients with late-onset epilepsy.


Johnson EL, Krauss GL, Kucharska-Newton A, et al. Mortality in patients with late-onset epilepsy: Results from the atherosclerosis risk in communities study. Neurology. Published online July 19, 2021. doi:10.1212/WNL.0000000000012483